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Animals were treated with a derivative of TGF alpha-PE40 in which the cysteine residues are replaced by alanine, termed "TGF alpha-PE40 delta cys," or with saline once a day for 5 days. The only toxicity to normal tissues was mild periportal hepatic necrosis.
These studies indicate that a therapeutic window exists in vivo for the use of some growth factor-toxin fusion proteins as anticancer agents. We do not capture any address. D C Heimbrook. Next. Back to top.
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Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing